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Solubility and release of fenamates intercalated in layered double hydroxides

¹ GIR-QUESCAT, Departamento de Química Inorgánica, Universidad de Salamanca, Salamanca, Spain, and ² Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Salamanca, Salamanca, Spain

^* E-mail: vrives{at}usal.es

(Received 17 October 2007; revised 20 January 2008)

The effect of a Mg- and Al-containing layered double hydroxide (LDH), used as an additive or as a matrix, on the dissolution and solubility of two non-steroidal anti-inflammatory drugs (NSAIDs), namely, mefenamic and meclofenamic acids, is reported. The use of MgAl-LDH enhances the solubility of mefenamic acid at the three pH values tested, and the value is larger when the acid is intercalated as opposed to simply being mixed with the layered material. For pure mefenamic acid, the most unfavourable pH is 1.2, while for the physical mixture and the sample with the intercalated drug, the most unfavourable pH is 4.5, for which the minimum increase in the amount of dissolved acid is recorded. The (dissolution) release-rate for both drugs when they are intercalated between the layers is much slower than for the physical mixture or for the dissolution of the pure drug.

KEYWORDS: hydrotalcite, anti-inflammatory, fenamate acids, controlled release, solubility, NSAID